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Pharmaceutical Polymorph Control in a Drug-Mimetic Supramolecular Gel

Foster, Jonathan A.; Damodaran, Krishna K.; Maurin, Antoine; Day, Graeme M.; Thompson, Hugh P.G.; Cameron, Gary J.; Bernal, Jenifer Cuesta; Steed, Jonathan W.

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Jonathan A. Foster

Krishna K. Damodaran

Antoine Maurin

Graeme M. Day

Hugh P.G. Thompson

Gary J. Cameron

Jenifer Cuesta Bernal


We report the synthesis of a bis(urea) gelator designed to specifically mimic the chemical structure of the highly polymorphic drug substance ROY. Crystallization of ROY from toluene gels of this gelator results in the formation of the metastable red form instead of the thermodynamic yellow polymorph. In contrast, all other gels and solution control experimetns give the yellow form. Conformational and crystal structure prediction methods have been used to propose the structure of the gel and shows that the templation of the red form by the targetted gel results from conformational matching of the gelator to the ROY substrate coupled with overgorwth of ROY onto the the local periodic structure of the gel fibres.


Foster, J. A., Damodaran, K. K., Maurin, A., Day, G. M., Thompson, H. P., Cameron, G. J., …Steed, J. W. (2017). Pharmaceutical Polymorph Control in a Drug-Mimetic Supramolecular Gel. Chemical Science, 8(1), 78-84.

Journal Article Type Article
Acceptance Date Oct 6, 2016
Online Publication Date Oct 7, 2016
Publication Date Jan 1, 2017
Deposit Date Oct 10, 2016
Publicly Available Date Oct 10, 2016
Journal Chemical Science
Print ISSN 2041-6520
Electronic ISSN 2041-6539
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 8
Issue 1
Pages 78-84


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