Skip to main content

Research Repository

Advanced Search

Approaching ‘kit-type’ labelling with 68Ga: the DATA chelators

Seemann, J.; Waldron, B.P.; Roesch, F.; Parker, D.

Approaching ‘kit-type’ labelling with 68Ga: the DATA chelators Thumbnail


J. Seemann

B.P. Waldron

F. Roesch


The DATA chelators are a novel class of tri-anionic ligands based on 6-amino-1,4-diazepine-triacetic acid, which have been introduced recently for the chelation of 68Ga. Compared with macrocyclic chelators based on the cyclen scaffold (i.e., DOTA, DO3A, and DO2A derivatives), DATA chelators undergo quantitative radiolabelling more rapidly and under milder conditions. In this study, a systematic evaluation of the labelling of four DATA chelators—DATAM, DATAP, DATAPh, and DATAPPh—with 68Ga is presented. The results highlight the extraordinary potential of this new class of chelators for application in molecular imaging using 68Ga positron emission tomography (PET).


Seemann, J., Waldron, B., Roesch, F., & Parker, D. (2015). Approaching ‘kit-type’ labelling with 68Ga: the DATA chelators. ChemMedChem, 10(6), 1019-1026.

Journal Article Type Article
Online Publication Date Apr 21, 2015
Publication Date Jun 1, 2015
Deposit Date Jul 20, 2015
Publicly Available Date Apr 21, 2016
Journal ChemMedChem
Print ISSN 1860-7179
Electronic ISSN 1860-7187
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 10
Issue 6
Pages 1019-1026
Keywords Chelates, Gallium-68, Ligand design, Macrocyclic ligands, Radiopharmaceuticals.


Accepted Journal Article (872 Kb)

Copyright Statement
This is the peer reviewed version of the following article: FSeemann, J., Waldron, B. P., Roesch, F. and Parker, D. (2015), Approaching ‘Kit-Type’ Labelling with 68Ga: The DATA Chelators. ChemMedChem, 10(6): 1019-1026, which has been published in final form at This article may be used for non-commercial purposes in accordance With Wiley-VCH Terms and Conditions for self-archiving.

You might also like

Downloadable Citations