J. Seemann
Approaching ‘kit-type’ labelling with 68Ga: the DATA chelators
Seemann, J.; Waldron, B.P.; Roesch, F.; Parker, D.
Abstract
The DATA chelators are a novel class of tri-anionic ligands based on 6-amino-1,4-diazepine-triacetic acid, which have been introduced recently for the chelation of 68Ga. Compared with macrocyclic chelators based on the cyclen scaffold (i.e., DOTA, DO3A, and DO2A derivatives), DATA chelators undergo quantitative radiolabelling more rapidly and under milder conditions. In this study, a systematic evaluation of the labelling of four DATA chelators—DATAM, DATAP, DATAPh, and DATAPPh—with 68Ga is presented. The results highlight the extraordinary potential of this new class of chelators for application in molecular imaging using 68Ga positron emission tomography (PET).
Citation
Seemann, J., Waldron, B., Roesch, F., & Parker, D. (2015). Approaching ‘kit-type’ labelling with 68Ga: the DATA chelators. ChemMedChem, 10(6), 1019-1026. https://doi.org/10.1002/cmdc.201500092
| Journal Article Type | Article |
|---|---|
| Online Publication Date | Apr 21, 2015 |
| Publication Date | Jun 1, 2015 |
| Deposit Date | Jul 20, 2015 |
| Publicly Available Date | Apr 21, 2016 |
| Journal | ChemMedChem |
| Print ISSN | 1860-7179 |
| Electronic ISSN | 1860-7187 |
| Publisher | Wiley |
| Peer Reviewed | Peer Reviewed |
| Volume | 10 |
| Issue | 6 |
| Pages | 1019-1026 |
| DOI | https://doi.org/10.1002/cmdc.201500092 |
| Keywords | Chelates, Gallium-68, Ligand design, Macrocyclic ligands, Radiopharmaceuticals. |
Files
Accepted Journal Article
(872 Kb)
PDF
Copyright Statement
This is the peer reviewed version of the following article: FSeemann, J., Waldron, B. P., Roesch, F. and Parker, D. (2015), Approaching ‘Kit-Type’ Labelling with 68Ga: The DATA Chelators. ChemMedChem, 10(6): 1019-1026, which has been published in final form at http://dx.doi.org/10.1002/cmdc.201500092. This article may be used for non-commercial purposes in accordance With Wiley-VCH Terms and Conditions for self-archiving.