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Simultaneous Triple Imaging with Two PARASHIFT Probes: Encoding Anatomical, pH and Temperature Information using Magnetic Resonance Shift Imaging

Finney, Katie-Louise N.A.; Harnden, Alice C.; Rogers, Nicola J.; Senanayake, P. Kanthi; Blamire, Andrew M.; O'Hogain, Dara; Parker, David

Simultaneous Triple Imaging with Two PARASHIFT Probes: Encoding Anatomical, pH and Temperature Information using Magnetic Resonance Shift Imaging Thumbnail


Authors

Katie-Louise N.A. Finney

Alice C. Harnden

Nicola J. Rogers

P. Kanthi Senanayake

Andrew M. Blamire

Dara O'Hogain



Abstract

The chemical shift of paramagnetically shifted resonances in lanthanide(III) complexes encodes information about temperature and has also been made to report pH in parallel, through introduction of a single phosphonate group adjacent to the reporter tert-butyl resonance. The enhanced sensitivity of this new probe has allowed the simultaneous triple imaging of the water signal and the shifted tert-butyl signals of thulium and dysprosium complexes of a common ligand, separated by over 160 ppm. In parallel spectral imaging experiments, the temperature and pH dependence of the frequency of the Tm and Dy signals has been deconvoluted, allowing the pH and temperature in the liver, kidney and bladder to be measured.

Citation

Finney, K. N., Harnden, A. C., Rogers, N. J., Senanayake, P. K., Blamire, A. M., O'Hogain, D., & Parker, D. (2017). Simultaneous Triple Imaging with Two PARASHIFT Probes: Encoding Anatomical, pH and Temperature Information using Magnetic Resonance Shift Imaging. Chemistry - A European Journal, 23(33), 7976-7989. https://doi.org/10.1002/chem.201700447

Journal Article Type Article
Online Publication Date May 22, 2017
Publication Date Jun 12, 2017
Deposit Date Jul 11, 2017
Publicly Available Date May 22, 2018
Journal Chemistry - A European Journal
Print ISSN 0947-6539
Electronic ISSN 1521-3765
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 23
Issue 33
Pages 7976-7989
DOI https://doi.org/10.1002/chem.201700447

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Accepted Journal Article (2.2 Mb)
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Copyright Statement
This is the accepted version of the following article: Finney, Katie-Louise N. A., Harnden, Alice C., Rogers, Nicola J., Senanayake, P. Kanthi, Blamire, Andrew M., O'Hogain, Dara & Parker, David (2017). Simultaneous Triple Imaging with Two PARASHIFT Probes: Encoding Anatomical, pH and Temperature Information using Magnetic Resonance Shift Imaging. Chemistry - A European Journal 23(33): 7976-7989 which has been published in final form at https://doi.org/10.1002/chem.201700447. This article may be used for non-commercial purposes in accordance With Wiley-VCH Terms and Conditions for self-archiving.


Accepted Journal Article (Supplementary material) (1.4 Mb)
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Copyright Statement
Supplementary material





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