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The Calcium-dependent protein kinase 1 from Toxoplasma gondii as target for structure-based drug design

Cardew, E.M.; Verlinde, C.L.J.M.; Pohl, E.

The Calcium-dependent protein kinase 1 from Toxoplasma gondii as target for structure-based drug design Thumbnail


Authors

E.M. Cardew

C.L.J.M. Verlinde



Abstract

The apicomplexan protozoan parasites include the causative agents of animal and human diseases ranging from malaria (Plasmodium spp.) to toxoplasmosis (Toxoplasma gondii). The complex life cycle of T. gondii is regulated by a unique family of calcium-dependent protein kinases (CDPKs) that have become the target of intensive efforts to develop new therapeutics. In this review, we will summarize structure-based strategies, recent successes and future directions in the pursuit of specific and selective inhibitors of T. gondii CDPK1.

Citation

Cardew, E., Verlinde, C., & Pohl, E. (2018). The Calcium-dependent protein kinase 1 from Toxoplasma gondii as target for structure-based drug design. Parasitology, 145(2), 210-218. https://doi.org/10.1017/s0031182017001901

Journal Article Type Article
Acceptance Date Aug 25, 2017
Online Publication Date Dec 1, 2017
Publication Date Feb 1, 2018
Deposit Date Sep 8, 2017
Publicly Available Date Sep 12, 2017
Journal Parasitology
Print ISSN 0031-1820
Electronic ISSN 1469-8161
Publisher Cambridge University Press
Peer Reviewed Peer Reviewed
Volume 145
Issue 2
Pages 210-218
DOI https://doi.org/10.1017/s0031182017001901

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Copyright Statement
© Cambridge University Press 2017. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/
by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.







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