The Calcium-dependent protein kinase 1 from Toxoplasma gondii as target for structure-based drug design

Cardew, E.M.; Verlinde, C.L.J.M.; Pohl, E.

Abstract

The apicomplexan protozoan parasites include the causative agents of animal and human diseases ranging from malaria (Plasmodium spp.) to toxoplasmosis (Toxoplasma gondii). The complex life cycle of T. gondii is regulated by a unique family of calcium-dependent protein kinases (CDPKs) that have become the target of intensive efforts to develop new therapeutics. In this review, we will summarize structure-based strategies, recent successes and future directions in the pursuit of specific and selective inhibitors of T. gondii CDPK1.

Citation

Cardew, E., Verlinde, C., & Pohl, E. (2018). The Calcium-dependent protein kinase 1 from Toxoplasma gondii as target for structure-based drug design. Parasitology, 145(2), 210-218. https://doi.org/10.1017/s0031182017001901

• Journal Article Type: Article
• Acceptance Date: Aug 25, 2017
• Online Publication Date: Dec 1, 2017
• Publication Date: Feb 1, 2018
• Deposit Date: Sep 8, 2017
• Publicly Available Date: Sep 12, 2017
• Journal: Parasitology
• Print ISSN: 0031-1820
• Electronic ISSN: 1469-8161
• Publisher: Cambridge University Press
• Peer Reviewed: Peer Reviewed
• Volume: 145
• Issue: 2
• Pages: 210-218
• DOI: https://doi.org/10.1017/s0031182017001901