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A concise flow synthesis of indole-3-carboxylic ester and its derivatisation to an auxin mimic

Baumann, Marcus; Baxendale, Ian R.; Deplante, Fabien

A concise flow synthesis of indole-3-carboxylic ester and its derivatisation to an auxin mimic Thumbnail


Authors

Marcus Baumann

Fabien Deplante



Abstract

An assembled suite of flow-based transformations have been used to rapidly scale-up the production of a novel auxin mimic-based herbicide which was required for preliminary field trials. The overall synthetic approach and optimisation studies are described along with a full description of the final reactor configurations employed for the synthesis as well as the downstream processing of the reaction streams.

Citation

Baumann, M., Baxendale, I. R., & Deplante, F. (2017). A concise flow synthesis of indole-3-carboxylic ester and its derivatisation to an auxin mimic. Beilstein Journal of Organic Chemistry, 13, 2549-2560. https://doi.org/10.3762/bjoc.13.251

Journal Article Type Article
Acceptance Date Nov 16, 2017
Online Publication Date Nov 29, 2017
Publication Date Nov 29, 2017
Deposit Date Nov 29, 2017
Publicly Available Date Nov 30, 2017
Journal Beilstein Journal of Organic Chemistry
Print ISSN 1860-5397
Publisher Beilstein-Institut
Peer Reviewed Peer Reviewed
Volume 13
Pages 2549-2560
DOI https://doi.org/10.3762/bjoc.13.251
Public URL https://durham-repository.worktribe.com/output/1343454

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Published Journal Article (1.6 Mb)
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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/

Copyright Statement
© 2017 Baumann et al.; licensee Beilstein-Institut. This is an Open Access article under the terms of the Creative Commons Attribution License
(http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.





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