Halogen and Hydrogen Bonding in Povidone-Iodine and Related Co-Phases

Goodwin, Melissa J.; Steed, Benjamin W.; Yufit, Dmitry S.; Musa, Osama M.; Berry, David J.; Steed, Jonathan W.

Abstract

Povidone-iodine is a widely used antiseptic and on the World Health Organization’s List of Essential Medicines. We report the X-ray crystal structure of a two-monomer unit model compound showing that the structure of povidone-iodine comprises protonated pyrrolidone units linked by intermolecular hydrogen bonds along with triiodide anions. We also report an unusual example of a system exhibiting both a cocrystal and coamorphous form in a halogen bonded lactam model compound with diiodotetrafluorobenzene.

Citation

Goodwin, M. J., Steed, B. W., Yufit, D. S., Musa, O. M., Berry, D. J., & Steed, J. W. (2017). Halogen and Hydrogen Bonding in Povidone-Iodine and Related Co-Phases. Crystal Growth and Design, 17(10), 5552-5558. https://doi.org/10.1021/acs.cgd.7b01103

• Journal Article Type: Article
• Acceptance Date: Sep 13, 2017
• Online Publication Date: Sep 18, 2017
• Publication Date: Oct 4, 2017
• Deposit Date: Oct 13, 2017
• Publicly Available Date: Sep 18, 2018
• Journal: Crystal Growth and Design
• Print ISSN: 1528-7483
• Electronic ISSN: 1528-7505
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• Volume: 17
• Issue: 10
• Pages: 5552-5558
• DOI: https://doi.org/10.1021/acs.cgd.7b01103