Melissa J. Goodwin
Halogen and Hydrogen Bonding in Povidone-Iodine and Related Co-Phases
Goodwin, Melissa J.; Steed, Benjamin W.; Yufit, Dmitry S.; Musa, Osama M.; Berry, David J.; Steed, Jonathan W.
Dmitry S. Yufit
Osama M. Musa
David J. Berry
Povidone-iodine is a widely used antiseptic and on the World Health Organization’s List of Essential Medicines. We report the X-ray crystal structure of a two-monomer unit model compound showing that the structure of povidone-iodine comprises protonated pyrrolidone units linked by intermolecular hydrogen bonds along with triiodide anions. We also report an unusual example of a system exhibiting both a cocrystal and coamorphous form in a halogen bonded lactam model compound with diiodotetrafluorobenzene.
Goodwin, M. J., Steed, B. W., Yufit, D. S., Musa, O. M., Berry, D. J., & Steed, J. W. (2017). Halogen and Hydrogen Bonding in Povidone-Iodine and Related Co-Phases. Crystal Growth and Design, 17(10), 5552-5558. https://doi.org/10.1021/acs.cgd.7b01103
|Journal Article Type||Article|
|Acceptance Date||Sep 13, 2017|
|Online Publication Date||Sep 18, 2017|
|Publication Date||Oct 4, 2017|
|Deposit Date||Oct 13, 2017|
|Publicly Available Date||Sep 18, 2018|
|Journal||Crystal Growth and Design|
|Publisher||American Chemical Society|
|Peer Reviewed||Peer Reviewed|
Accepted Journal Article
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth & Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.cgd.7b01103.
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