Tailored Supramolecular Gel and Microemulsion Crystallization Strategies – is Isoniazid Really Monomorphic?

Kennedy, Stuart R.; Jones, Christopher D.; Yufit, Dimitrii S.; Nicholson, Catherine Emma; Cooper, Sharon J.; Steed, Jonathan W.

Abstract

We report the application of supramolecular gel and microemulsion droplet crystallisation methodologies to isoniazid crystallization. Tailored gelators have been designed with isoniazid mimetic functionality in an attempt to control crystal morphology and polymorphic behaviour. Microemulsion crystallisation was investigated to achieve thermodynamic control over drug crystallisation. Both techniques resulted in only a single form of isoniazid implying that it is genuinely monomorphic.

Citation

Kennedy, S. R., Jones, C. D., Yufit, D. S., Nicholson, C. E., Cooper, S. J., & Steed, J. W. (2018). Tailored Supramolecular Gel and Microemulsion Crystallization Strategies – is Isoniazid Really Monomorphic?. CrystEngComm, 20(10), 1390-1398. https://doi.org/10.1039/c8ce00066b

• Journal Article Type: Article
• Acceptance Date: Feb 10, 2018
• Online Publication Date: Feb 12, 2018
• Publication Date: Mar 14, 2018
• Deposit Date: Feb 13, 2018
• Publicly Available Date: Feb 10, 2019
• Journal: CrystEngComm
• Electronic ISSN: 1466-8033
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 20
• Issue: 10
• Pages: 1390-1398
• DOI: https://doi.org/10.1039/c8ce00066b
• Public URL: https://durham-repository.worktribe.com/output/1334809