High thermal stability, pH responsive organogels of 2H-benzo[d]1,2,3-triazole derivatives as pharmaceutical crystallization media

Torres-Moya, Iván; Saikia, Basanta; Prieto, Pilar; Carrillo, José R.; Steed, Jonathan W.

Abstract

2H-Benzo[d]1,2,3-triazole derivatives with a range of chemical functionalities showed significant organogel formation, particularly bis-amide derivative 4e which gave robust thermally stable gels, in a range of solvents down to 0.1 wt%. The gelators proved responsive under pH stimuli or to the presence of metal cations. The gels also proved to be useful vehicles to crystallize pharmaceutical drugs, resulting in a change in polymorphic outcome in the case of sulfathiazole compared to the solution crystallization outcome.

Citation

Torres-Moya, I., Saikia, B., Prieto, P., Carrillo, J. R., & Steed, J. W. (2019). High thermal stability, pH responsive organogels of 2H-benzo[d]1,2,3-triazole derivatives as pharmaceutical crystallization media. CrystEngComm, 21(13), 2135-2143. https://doi.org/10.1039/c8ce01742e

• Journal Article Type: Article
• Acceptance Date: Nov 27, 2018
• Online Publication Date: Nov 27, 2018
• Publication Date: Apr 7, 2019
• Deposit Date: Mar 26, 2019
• Publicly Available Date: Nov 27, 2019
• Journal: CrystEngComm
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 21
• Issue: 13
• Pages: 2135-2143
• DOI: https://doi.org/10.1039/c8ce01742e