Dynamic morphologies and stability of droplet interface bilayers
Guiselin, B.; Law, J.O.; Chakrabarti, B.; Kusumaatmaja, H.
Professor Halim Kusumaatmaja email@example.com
We develop a theoretical framework for understanding dynamic morphologies and stability of droplet interface bilayers (DIBs), accounting for lipid kinetics in the monolayers and bilayer, and droplet evaporation due to imbalance between osmotic and Laplace pressures. Our theory quantitatively describes distinct pathways observed in experiments when DIBs become unstable. We find that when the timescale for lipid desorption is slow compared to droplet evaporation, the lipid bilayer will grow and the droplets approach a hemispherical shape. In contrast, when lipid desorption is fast, the bilayer area will shrink and the droplets eventually detach. Our model also suggests there is a critical size below which DIBs can become unstable, which may explain experimental difficulties in miniaturizing the DIB platform.
Guiselin, B., Law, J., Chakrabarti, B., & Kusumaatmaja, H. (2018). Dynamic morphologies and stability of droplet interface bilayers. Physical Review Letters, 120(23), Article 238001. https://doi.org/10.1103/physrevlett.120.238001
|Journal Article Type||Article|
|Acceptance Date||May 7, 2018|
|Online Publication Date||Jun 6, 2018|
|Publication Date||Jun 6, 2018|
|Deposit Date||May 30, 2018|
|Publicly Available Date||Jun 12, 2018|
|Journal||Physical Review Letters|
|Publisher||American Physical Society|
|Peer Reviewed||Peer Reviewed|
|Related Public URLs||https://arxiv.org/abs/1803.08262|
Published Journal Article
Publisher Licence URL
Accepted Journal Article
Published by the American Physical Society under the terms of the Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI.
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