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Photoactivated cell-killing involving a low molecular weight, donor-acceptor diphenylacetylene

Chisholm, David; Lamb, Rebecca; Pallett, Tommy; Affleck, Valerie; Holden, Claire; Marrison, Joanne; O'Toole, Peter; Ashton, Peter; Newling, Katherine; Steffen, Andreas; Nelson, Amanda; Mahler, Christoph; Valentine, Roy; Blacker, Thomas; Bain, Angus John; Girkin, John M; Marder, Todd B; Whiting, Andrew; Ambler, Carrie A

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David Chisholm

Rebecca Lamb

Tommy Pallett

Claire Holden

Joanne Marrison

Peter O'Toole

Peter Ashton

Katherine Newling

Andreas Steffen

Amanda Nelson

Christoph Mahler

Roy Valentine

Thomas Blacker

Angus John Bain

Todd B Marder


Photoactivation of photosensitisers can be utilised to elicit the production of ROS, for potential therapeutic applications, including the destruction of diseased tissues and tumours. A novel class of photosensitiser, exemplified by DC324, has been designed possessing a modular, low molecular weight ‘drug-like’ structure which is bioavailable and can be photoactivated by UV-A/405 nm or corresponding two-photon absorption of near-IR (800 nm) light, resulting in powerful cytotoxic activity, ostensibly through the production of ROS in a cellular environment. A variety of in vitro cellular assays confirmed ROS formation and in vivo cytotoxic activity was exemplified via irradiation and subsequent targeted destruction of specific areas of a zebrafish embryo.


Chisholm, D., Lamb, R., Pallett, T., Affleck, V., Holden, C., Marrison, J., …Ambler, C. A. (2019). Photoactivated cell-killing involving a low molecular weight, donor-acceptor diphenylacetylene. Chemical Science, 10(17), 4673-4683.

Journal Article Type Article
Acceptance Date Mar 20, 2019
Online Publication Date Mar 21, 2019
Publication Date May 7, 2019
Deposit Date Mar 21, 2019
Publicly Available Date Mar 20, 2020
Journal Chemical Science
Print ISSN 2041-6520
Electronic ISSN 2041-6539
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 10
Issue 17
Pages 4673-4683


Accepted Journal Article (2.5 Mb)

Copyright Statement
This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

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