Dr John Sanderson j.m.sanderson@durham.ac.uk
Associate Professor
Far From Inert: Membrane Lipids Possess Intrinsic Reactivity That Has Consequences For Cell Biology
Sanderson, John M
Authors
Abstract
In this article, it is hypothesized that a fundamental chemical reactivity exists between some non‐lipid constituents of cellular membranes and ester‐based lipids, the significance of which is not generally recognized. Many peptides and smaller organic molecules have now been shown to undergo lipidation reactions in model membranes in circumstances where direct reaction with the lipid is the only viable route for acyl transfer. Crucially, drugs like propranolol are lipidated in vivo with product profiles that are comparable to those produced in vitro. Some compounds have also been found to promote lipid hydrolysis. Drugs with high lytic activity in vivo tend to have higher toxicity in vitro. Deacylases and lipases are proposed as key enzymes that protect cells against the effects of intrinsic lipidation. The toxic effects of intrinsic lipidation are hypothesized to include a route by which nucleation can occur during the formation of amyloid fibrils.
Citation
Sanderson, J. M. (2020). Far From Inert: Membrane Lipids Possess Intrinsic Reactivity That Has Consequences For Cell Biology. BioEssays, 42(3), Article 1900147. https://doi.org/10.1002/bies.201900147
Journal Article Type | Article |
---|---|
Acceptance Date | Dec 12, 2019 |
Online Publication Date | Jan 29, 2020 |
Publication Date | Mar 31, 2020 |
Deposit Date | Dec 16, 2019 |
Publicly Available Date | Jan 29, 2021 |
Journal | BioEssays |
Print ISSN | 0265-9247 |
Electronic ISSN | 1521-1878 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Volume | 42 |
Issue | 3 |
Article Number | 1900147 |
DOI | https://doi.org/10.1002/bies.201900147 |
Public URL | https://durham-repository.worktribe.com/output/1280642 |
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Copyright Statement
This is the accepted version of the following article: Sanderson, John M (2020). Far From Inert: Membrane Lipids Possess Intrinsic Reactivity That Has Consequences For Cell Biology. BioEssays 42(3): 1900147 which has been published in final form at https://doi.org/10.1002/bies.201900147. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for self-archiving.
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