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Cumulative dietary risk characterisation of pesticides that have chronic effects on the thyroid

Craig, Peter S; Dujardin, Bruno; Hart, Andy; Hernandez‐Jerez, Antonio F; Hougaard Bennekou, Susanne; Kneuer, Carsten; Ossendorp, Bernadette; Pedersen, Ragnor; Wolterink, Gerrit; Mohimont, Luc

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Bruno Dujardin

Andy Hart

Antonio F Hernandez‐Jerez

Susanne Hougaard Bennekou

Carsten Kneuer

Bernadette Ossendorp

Ragnor Pedersen

Gerrit Wolterink

Luc Mohimont


A retrospective chronic cumulative risk assessment of dietary exposure to pesticide residues, supported by an uncertainty analysis based on expert knowledge elicitation, was conducted for two effects on the thyroid, hypothyroidism and parafollicular cell (C‐cell) hypertrophy, hyperplasia and neoplasia. The pesticides considered in this assessment were identified and characterised in the scientific report on the establishment of cumulative assessment groups of pesticides for their effects on the thyroid. Cumulative exposure assessments were conducted through probabilistic modelling by EFSA and the Dutch National Institute for Public Health and the Environment (RIVM) using two different software tools and reported separately. These exposure assessments used monitoring data collected by Member States under their official pesticide monitoring programmes in 2014, 2015 and 2016 and individual consumption data from 10 populations of consumers from different countries and different age groups. This report completes the characterisation of cumulative risk, taking account of the available data and the uncertainties involved. For each of the 10 populations, it is concluded with varying degrees of certainty that cumulative exposure to pesticides that have the chronic effects on the thyroid mentioned above does not exceed the threshold for regulatory consideration established by risk managers.


Craig, P. S., Dujardin, B., Hart, A., Hernandez‐Jerez, A. F., Hougaard Bennekou, S., Kneuer, C., …Mohimont, L. (2020). Cumulative dietary risk characterisation of pesticides that have chronic effects on the thyroid. EFSA Journal, 18(4), Article e06088.

Journal Article Type Article
Online Publication Date Apr 29, 2020
Publication Date 2020-04
Deposit Date Oct 22, 2020
Publicly Available Date Dec 9, 2020
Journal EFSA Journal
Print ISSN 1831-4732
Publisher Wiley Open Access
Peer Reviewed Peer Reviewed
Volume 18
Issue 4
Article Number e06088


Published Journal Article (8.8 Mb)

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Copyright Statement
© 2020 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. This is an open access article under the terms of the Creative Commons Attribution‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.

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