Yonghong Zhang
Lanthanide–Cyclen–Camptothecin Nanocomposites for Cancer Theranostics Guided by Near-Infrared and Magnetic Resonance Imaging
Zhang, Yonghong; Ma, Xia; Chau, Ho-Fai; Thor, Waygen; Jiang, Lijun; Zha, Shuai; Fok, Wan-Yiu; Mak, Ho-Nam; Zhang, Junhui; Cai, Jing; Ng, Chi-Fai; Li, Hongguang; Parker, David; Li, Li; Law, Ga-Lai; Wong, Ka-Leung
Authors
Xia Ma
Ho-Fai Chau
Waygen Thor
Lijun Jiang
Shuai Zha
Wan-Yiu Fok
Ho-Nam Mak
Junhui Zhang
Jing Cai
Chi-Fai Ng
Hongguang Li
Professor David Parker david.parker@durham.ac.uk
Professor
Li Li
Ga-Lai Law
Ka-Leung Wong
Abstract
We have devised a molecular-to-micellar strategy to incorporate a lanthanide nanoplatform for the delivery of an anticancer drug that simultaneously offers hybrid near-infrared (NIR) and magnetic resonance imaging (MRI) capabilities with defined lanthanide(III) ratio control. This cancer-selective lanthanide-based self-assembled nanocomposite (LnNPs) has been synthesized by conjugating lanthanide–cyclen complexes (cycLn) with a well-known drug–camptothecin (CPT) through a redox-sensitive disulfide bond (−ss–). By accurately controlling the ratio of Gd(III) and Yb(III) complexes, we prepared hybrid nanoparticles (Gd/YbNPs) with both NIR and MR imaging properties. The enhanced stability at ultralow critical aggregation concentrations (CACs), simultaneous optical and MR imaging, improved delivery/chemotherapeutic efficiency, and cancer cell selectivity of such nanomicellar theranostic prodrugs in vitro and in vivo have thus been achieved and validated. The work provides a blueprint combining a stimuli-activated NIR luminescence and real-time MR imaging into a safe and biocompatible nanoplatform for selective cancer treatment.
Citation
Zhang, Y., Ma, X., Chau, H., Thor, W., Jiang, L., Zha, S., …Wong, K. (2021). Lanthanide–Cyclen–Camptothecin Nanocomposites for Cancer Theranostics Guided by Near-Infrared and Magnetic Resonance Imaging. ACS Applied Nano Material, 4(1), 271-278. https://doi.org/10.1021/acsanm.0c02597
| Journal Article Type | Article |
|---|---|
| Acceptance Date | Dec 11, 2020 |
| Online Publication Date | Jan 4, 2021 |
| Publication Date | Jan 22, 2021 |
| Deposit Date | Jun 4, 2021 |
| Publicly Available Date | Jan 4, 2022 |
| Journal | ACS applied nano materials. |
| Electronic ISSN | 2574-0970 |
| Publisher | American Chemical Society |
| Peer Reviewed | Peer Reviewed |
| Volume | 4 |
| Issue | 1 |
| Pages | 271-278 |
| DOI | https://doi.org/10.1021/acsanm.0c02597 |
Files
Accepted Journal Article
(769 Kb)
PDF
Copyright Statement
This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Nano Materials, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsanm.0c02597.