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Protein metalation in biology

Foster, Andrew W.; Young, Tessa R.; Chivers, Peter T.; Robinson, Nigel J.

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Authors

Andrew W. Foster



Abstract

Inorganic metals supplement the chemical repertoire of organic molecules, especially proteins. This requires the correct metals to associate with proteins at metalation. Protein mismetalation typically occurs when excesses of unbound metals compete for a binding site ex vivo. However, in biology, excesses of metal-binding sites typically compete for limiting amounts of exchangeable metals. Here, we summarise mechanisms of metal homeostasis that sustain optimal metal availabilities in biology. We describe recent progress to understand metalation by comparing the strength of metal binding to a protein versus the strength of binding to competing sites inside cells.

Citation

Foster, A. W., Young, T. R., Chivers, P. T., & Robinson, N. J. (2022). Protein metalation in biology. Current Opinion in Chemical Biology, 66, Article 102095. https://doi.org/10.1016/j.cbpa.2021.102095

Journal Article Type Article
Online Publication Date Nov 8, 2021
Publication Date 2022-02
Deposit Date Nov 19, 2021
Publicly Available Date Dec 7, 2021
Journal Current Opinion in Chemical Biology
Print ISSN 1367-5931
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 66
Article Number 102095
DOI https://doi.org/10.1016/j.cbpa.2021.102095

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