Luis Baudouin-Gonzalez
Regulation of Eye Determination and Regionalization in the Spider Parasteatoda tepidariorum
Baudouin-Gonzalez, Luis; Harper, Amber; McGregor, Alistair P.; Sumner-Rooney, Lauren
Authors
Amber Harper
Professor Alistair McGregor alistair.mcgregor@durham.ac.uk
Professor
Lauren Sumner-Rooney
Abstract
Animal visual systems are enormously diverse, but their development appears to be controlled by a set of conserved retinal determination genes (RDGs). Spiders are particular masters of visual system innovation, and offer an excellent opportunity to study the evolution of animal eyes. Several RDGs have been identified in spider eye primordia, but their interactions and regulation remain unclear. From our knowledge of RDG network regulation in Drosophila melanogaster, we hypothesize that orthologs of Pax6, eyegone, Wnt genes, hh, dpp, and atonal could play important roles in controlling eye development in spiders. We analyzed the expression of these genes in developing embryos of the spider Parasteatodatepidariorum, both independently and in relation to the eye primordia, marked using probes for the RDG sine oculis. Our results support conserved roles for Wnt genes in restricting the size and position of the eye field, as well as for atonal initiating photoreceptor differentiation. However, we found no strong evidence for an upstream role of Pax6 in eye development, despite its label as a master regulator of animal eye development; nor do eyg, hh or dpp compensate for the absence of Pax6. Conversely, our results indicate that hh may work with Wnt signaling to restrict eye growth, a role similar to that of Sonichedgehog (Shh) in vertebrates.
Citation
Baudouin-Gonzalez, L., Harper, A., McGregor, A. P., & Sumner-Rooney, L. (2022). Regulation of Eye Determination and Regionalization in the Spider Parasteatoda tepidariorum. Cells, 11(4), Article 631. https://doi.org/10.3390/cells11040631
Journal Article Type | Article |
---|---|
Acceptance Date | Feb 4, 2022 |
Online Publication Date | Feb 11, 2022 |
Publication Date | 2022-02 |
Deposit Date | Jul 6, 2022 |
Publicly Available Date | Jul 6, 2022 |
Journal | Cells |
Electronic ISSN | 2073-4409 |
Publisher | MDPI |
Peer Reviewed | Peer Reviewed |
Volume | 11 |
Issue | 4 |
Article Number | 631 |
DOI | https://doi.org/10.3390/cells11040631 |
Public URL | https://durham-repository.worktribe.com/output/1201857 |
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Copyright Statement
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
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