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Carbon Dioxide and the Carbamate Post-Translational Modification

Blake, Lynsay I.; Cann, Martin J.

Carbon Dioxide and the Carbamate Post-Translational Modification Thumbnail


Lynsay I. Blake


Carbon dioxide is essential for life. It is at the beginning of every life process as a substrate of photosynthesis. It is at the end of every life process as the product of post-mortem decay. Therefore, it is not surprising that this gas regulates such diverse processes as cellular chemical reactions, transport, maintenance of the cellular environment, and behaviour. Carbon dioxide is a strategically important research target relevant to crop responses to environmental change, insect vector-borne disease and public health. However, we know little of carbon dioxide’s direct interactions with the cell. The carbamate post-translational modification, mediated by the nucleophilic attack by carbon dioxide on N-terminal α-amino groups or the lysine ɛ-amino groups, is one mechanism by which carbon dioxide might alter protein function to form part of a sensing and signalling mechanism. We detail known protein carbamates, including the history of their discovery. Further, we describe recent studies on new techniques to isolate this problematic post-translational modification.


Blake, L. I., & Cann, M. J. (2022). Carbon Dioxide and the Carbamate Post-Translational Modification. Frontiers in Molecular Biosciences, 9, Article 825706.

Journal Article Type Article
Acceptance Date Feb 3, 2022
Online Publication Date Mar 1, 2022
Publication Date 2022
Deposit Date Jul 18, 2022
Publicly Available Date Jul 18, 2022
Journal Frontiers in Molecular Biosciences
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 9
Article Number 825706
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Published Journal Article (1.3 Mb)

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Copyright Statement
© 2022 Blake and Cann. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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