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Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks

Hoffmann, S.; Aiassa, E.; Angrish, M.; Beausoleil, C.; Bois, F.Y.; Ciccolallo, L.; Craig, P.S.; de Vries, R.B.M.; Dorne, J.L.C.M.; Druwe, I.L.; Edwards, S.W.; Eskes, C.; Georgiadis, M.; Hartung, T.; Kienzler, A.; Kristjansson, E.A.; Lam, J.; Martino, L.; Meek, B.; Morgan, R.L.; Munoz-Guajardo, I.; Noyes, P.D.; Parmelli, E.; Piersma, A.; Rooney, A.; Sena, E.; Sullivan, K.; Tarazona, J.; Terron, A.; Thayer, K.; Turner, J.; Verbeek, J.; Verloo, D.; Vinken, M.; Watford, S.; Whaley, P.; Wikoff, D.; Willett, K.; Tsaioun, K.

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S. Hoffmann

E. Aiassa

M. Angrish

C. Beausoleil

F.Y. Bois

L. Ciccolallo

R.B.M. de Vries

J.L.C.M. Dorne

I.L. Druwe

S.W. Edwards

C. Eskes

M. Georgiadis

T. Hartung

A. Kienzler

E.A. Kristjansson

J. Lam

L. Martino

B. Meek

R.L. Morgan

I. Munoz-Guajardo

P.D. Noyes

E. Parmelli

A. Piersma

A. Rooney

E. Sena

K. Sullivan

J. Tarazona

A. Terron

K. Thayer

J. Turner

J. Verbeek

D. Verloo

M. Vinken

S. Watford

P. Whaley

D. Wikoff

K. Willett

K. Tsaioun


The workshop titled “Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks” was co-organized by the Evidence-based Toxicology Collaboration and the European Food Safety Authority (EFSA) and hosted by EFSA at its headquarters in Parma, Italy on October 2 and 3, 2019. The goal was to explore integration of systematic review with mechanistic evidence evaluation. Participants were invited to work on concrete products to advance the exploration of how evidence-based approaches can support the development and application of adverse outcome pathways (AOP) in chemical risk assessment. The workshop discussions were centered around three related themes: 1) assessing certainty in AOPs, 2) literature-based AOP development, and 3) integrating certainty in AOPs and non-animal evidence into decision frameworks. Several challenges, mostly related to methodology, were identified and largely determined the workshop recommendations. The workshop recommendations included the comparison and potential alignment of processes used to develop AOP and systematic review methodology, including the translation of vocabulary of evidence-based methods to AOP and vice versa, the development and improvement of evidence mapping and text mining methods and tools, as well as a call for a fundamental change in chemical risk and uncertainty assessment methodology if to be conducted based on AOPs and new approach methodologies (NAM). The usefulness of evidence-based approaches for mechanism-based chemical risk assessments was stressed, particularly the potential contribution of the rigor and transparency inherent to such approaches in building stakeholders’ trust for implementation of NAM evidence and AOPs into chemical risk assessment.


Hoffmann, S., Aiassa, E., Angrish, M., Beausoleil, C., Bois, F., Ciccolallo, L., …Tsaioun, K. (2022). Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks. ALTEX - Alternatives to Animal Experimentation, 39(3), 499-518.

Journal Article Type Article
Online Publication Date Jul 20, 2022
Publication Date 2022
Deposit Date Nov 29, 2022
Publicly Available Date Nov 29, 2022
Journal ALTEX
Print ISSN 1868-596X
Publisher ALTEX Edition
Peer Reviewed Peer Reviewed
Volume 39
Issue 3
Pages 499-518


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Copyright Statement
This work is licensed under a Creative Commons Attribution 4.0 International License.

Articles are distributed under the terms of the Creative Commons Attribution 4.0 International license (, which permits unrestricted use, distribution and reproduction in any medium, provided the original work is appropriately cited (CC-BY). Copyright on any article in ALTEX is retained by the author(s).

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