Jessica L. Andrews
Vapor Sorption and Halogen-Bond-Induced Solid-Form Rearrangement of a Porous Pharmaceutical
Andrews, Jessica L.; Yufit, Dmitry S.; McCabe, James F.; Fox, Mark A.; Steed, Jonathan W.
Authors
Dr Dmitry Yufit d.s.yufit@durham.ac.uk
Academic Visitor
James F. McCabe
Dr Mark Fox m.a.fox@durham.ac.uk
Assistant Professor
Professor Jonathan Steed jon.steed@durham.ac.uk
Professor
Abstract
A porous, nonsolvated polymorph of the voltage-gated sodium channel blocker mexiletine hydrochloride absorbs iodine vapor to give a pharmaceutical cocrystal incorporating an I2Cl– anion that forms a halogen−π interaction with the mexiletine cations. The most thermodynamically stable form of the compound does not absorb iodine. This example shows that vapor sorption is a potentially useful and underused tool for bringing about changes in pharmaceutical solid form as part of a solid form screening protocol.
Citation
Andrews, J. L., Yufit, D. S., McCabe, J. F., Fox, M. A., & Steed, J. W. (2023). Vapor Sorption and Halogen-Bond-Induced Solid-Form Rearrangement of a Porous Pharmaceutical. Crystal Growth and Design, 23(4), 2628-2633. https://doi.org/10.1021/acs.cgd.2c01464
Journal Article Type | Article |
---|---|
Online Publication Date | Feb 28, 2023 |
Publication Date | 2023 |
Deposit Date | Apr 27, 2023 |
Publicly Available Date | Apr 27, 2023 |
Journal | Crystal Growth & Design |
Print ISSN | 1528-7483 |
Electronic ISSN | 1528-7505 |
Publisher | American Chemical Society |
Peer Reviewed | Peer Reviewed |
Volume | 23 |
Issue | 4 |
Pages | 2628-2633 |
DOI | https://doi.org/10.1021/acs.cgd.2c01464 |
Public URL | https://durham-repository.worktribe.com/output/1175533 |
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http://creativecommons.org/licenses/by/4.0/
Copyright Statement
This work is licensed under a Creative Commons Attribution 4.0 International License.
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